The core Israeli cell death community encompasses a few dozen research groups engaged in the exploration of the cellular and molecular mechanisms underlying the different pathways of cell death in all organisms. Local researchers utilize a variety of in vitro and in vivo systems and are involved in varied studies, ranging from exploration of the core cell death machineries, as well as tangential cellular processes associated with cell death components, through the uncovering of different roles of cell death in development, homeostasis and in the pathology of diseases, to translational studies aiming to utilize this knowledge to fight different disease (see the list of groups and topics).
The roles of TAM receptors and their ligands PROS1 and GAS6 in phagocytosis and inflammation in health and disease.
Regulated necrotic cell death activated by pore-forming proteins: identification of positive and negative regulators.
Interactions of cell death-related proteins, intrinsic disorder in cell death-related proteins, peptide inhibitors of cell death-related proteins.
Cell Death and Immune Response: Mechanisms of Necroptosis and Pyroptosis and their role in Inflammation.
Spatial and temporal regulation of cell fate determination, cell proliferation and cell death and survival during normal and aberrant organ formation.
Signal transduction in cancer – the response to stress and chemotherapy by protein kinases and upstream open reading frames (uORFs)-encoded peptides.
Autoimmunity, immune deficiency and autoinflammatory conditions related to huaman mutations affecting cell death and clearance of dying cells.
Uncovering the function of the mitochondrial protein VDAC1 in the regulation of cell life and death.
Investigating the cellular and molecular mechanisms that control the wiring of the nervous system.