The core Israeli cell death community encompasses a few dozen research groups engaged in the exploration of the cellular and molecular mechanisms underlying the different pathways of cell death in all organisms. Local researchers utilize a variety of in vitro and in vivo systems and are involved in varied studies, ranging from exploration of the core cell death machineries, as well as tangential cellular processes associated with cell death components, through the uncovering of different roles of cell death in development, homeostasis and in the pathology of diseases, to translational studies aiming to utilize this knowledge to fight different disease (see the list of groups and topics).
Society Members
Caspases without death and death without caspases in development.
Apoptotic cell clearance and its consequences in inflammation and its resolution.
Redox signaling in inflammation and cancer.
Signaling of inflammation and cancer through genetically-modified mice
The role of Livin in health and disease.
The roles of TAM receptors and their ligands PROS1 and GAS6 in phagocytosis and inflammation in health and disease.
Program cell death in bacteria
Regulated necrotic cell death activated by pore-forming proteins: identification of positive and negative regulators.
Interactions of cell death-related proteins, intrinsic disorder in cell death-related proteins, peptide inhibitors of cell death-related proteins.
The role of programmed cell death in stem cells.
Cell Death and Immune Response: Mechanisms of Necroptosis and Pyroptosis and their role in Inflammation.
Spatial and temporal regulation of cell fate determination, cell proliferation and cell death and survival during normal and aberrant organ formation.
Senescent cells in Hodgkin’s lymphoma.
Metabolic vulnerabilities of cancer.
Mitochondria in the center of cell fate decisions.
The Protein Interaction Map of Programmed Cell Death in Development and Disease.
Cellular senescence in aging, cancer and embryonic development.
Cell clearance mechanisms during development and aging.
Molecular mechanisms of cell death and cancer.
Signal transduction in cancer – the response to stress and chemotherapy by protein kinases and upstream open reading frames (uORFs)-encoded peptides.
Mechanisms involved in pancreatic beta cell death in diabetes.
Autoimmunity, immune deficiency and autoinflammatory conditions related to huaman mutations affecting cell death and clearance of dying cells.
Functional analysis of the p53 and Hippo pathways.
A multidisciplinary approach to study the extracellular matrix.
Uncovering the function of the mitochondrial protein VDAC1 in the regulation of cell life and death.
Canonical and non-canonical actions of Bcl-2 family proteins
Tissue regeneration, adult stem cells and aging using Drosophila model organism.
Signaling for cell death and for cell survival mechanisms by the TNF cytokine family.
Investigating the cellular and molecular mechanisms that control the wiring of the nervous system.